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Migrastat (Sumatriptan)

The selective 5-HT1D-receptor agonist L-775,606 has less propensity towards vasoconstriction in human isolated coronary artery (endothelium-denuded) than was mixed 5-HT1B/1D-receptor agonist Migrastat. Both 1 week after oral Migrastat and 1 week after discontinuation of the drug, visual analog scale scores resulted in a significant decrease from the baseline.

Other names for this medication:
Sumatriptan, Imitrex, Amigrenex, Amigrenin, Cinie, Forcet, Formigran, Imigran, Imigrane, Imiject, Migranol, Migrastat, Migrex, Nograine, Sitran, Suma, Sumagen, Sumamigren, Sumatab, Sumatran, Sumetrin, Sumigran, Suminat, Sumitran, Sumitrex, Suvalan, Zumo,

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Migrastat is used to treat migraines. It helps to relieve headache, pain, and other migraine symptoms (including nausea, vomiting, sensitivity to light/sound). Prompt treatment helps you return to your normal routine and may decrease your need for other pain medications. Migrastat belongs to a class of drugs known as triptans. It affects a certain natural substance (serotonin) that causes narrowing of blood vessels in the brain. It may also relieve pain by affecting certain nerves in the brain. Migrastat does not prevent future migraines or lessen how often you get migraine attacks.

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Two approaches were compared: (i) herpes simplex virus thymidine kinase (TK)/ganciclovir (GCV) and (ii) yeast cytosine deaminase fused with uracil phosphoribosyltransferase (CD::UPRT)/5-fluorocytosine (5-FC). The MRI findings were subsequently compared with histopathologic data of surgical specimens with reference to the presence of cortical and/or medullary mandibular involvement. An update on the biological activity of indazoles is also surveyed.

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Intracerebroventricular administration of apo A-IV antiserum stimulated feeding and decreased the hypothalamic apo A-IV mRNA level, implying that feeding is intimately regulated by endogenous hypothalamic apo A-IV. To assess the reliability and negative predictive value of voiding cystourethrogram (VCUG) performed within 24 hours postoperatively. We thus studied the feasibility of introducing first-aid training to 6-7-year old primary school children. A phase II trial of capecitabine (Xeloda) in recurrent ovarian cancer. The age at which drug therapy should be started is still controversial, as is the use of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins).

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The increased protein stability of p27 likely resulted from IBET-mediated suppression of Skp2, an E3 ligase that can mediate p27 degradation by increasing its ubiquitinylation. Asymptomatic Mycoplasma genitalium infection amongst marginalised young people accessing a youth health service in Melbourne. For many diseases the infection status of individuals cannot be observed directly, but can only be inferred from biomarkers that are subject to measurement error. Bone scan, MRI, and FDG PET/CT findings in composite hemangioendothelioma of the manubrium sterni. Despite added risk associated with unintended pregnancy, many women who receive Category X medications have refill patterns suggesting nonadherence to oral contraception.

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Total and conceptual vocabulary in Spanish-English bilinguals from 22 to 30 months: implications for assessment. It is suggested that the polymerization of Ca-polyhedra is responsible for the fragile viscosity behavior of the melt and the glass forming ability in CaSiO(3). We report a rare case of spinal cord capillary hemangioma in a 79-year-old woman, presented with paraparesia that had progressed within 8 months. Three research topics that were considered by the HTA panels in the September 2002 and February 2003 prioritisation rounds.

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Though opioids provide good analgesia, they are far from being an ideal analgesic due to their adverse effects. Both treatments were well tolerated and showed a significant improvement of skin and hormonal parameters, although EE/DRSP showed a more potent effect on acne and seborrhea.

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Research use of leftover newborn bloodspots: attitudes of Canadian geneticists regarding storage and informed consent requirements. Using estimates of migration from mtDNA haplotypes between dark- and light-colored sampling sites and Mc1r allele frequencies at each site, we estimated selection coefficients against mismatched Mc1r alleles, assuming a simple model of migration-selection balance. Effect of meteorological variables on Plasmodium vivax and Plasmodium falciparum malaria in outbreak prone districts of Rajasthan, India. Two children (age 3y and 7y) with recurrent gastrointestinal bleeding.

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In the water maze test, the animals were trained to find a platform in a fixed position during 6 days and then received a 60-s probe trial in which the platform was removed from the pool on the 7th day. The neuroprotective effects of aspirin on focal cerebral ischemia-reperfusion rats might be attributed to its effects by increasing the ratio of PGI2 and TXA2, reducing lipid peroxides and improving the energy metabolism.

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There were 47 trabeculectomy eyes (44 patients) and 47 cataract extraction eyes (46 patients) matched for age, sex, race, systemic medications, and type of anaesthetic. The aim of this study was to determine whether the preoperative serum cystatin C (pre-CysC) level could predict clinical outcomes after treatment in patients with postrenal AKI. burgdorferi strain 31, available for more than a decade, has assisted research on the pathogenesis of Lyme disease.

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Three-factor structure for Epistemic Belief Inventory: A cross-validation study. We demonstrate that this filter has good fabrication tolerances for the grating thickness and fill factor. Mutations or lack of expression of these subunits have significant pathogenic consequences in humans. The purpose is to (1) develop improved measurement instruments for clinical trials, (2) evaluate longitudinal performance of a variety of patient-reported outcome measures, (3) develop prognostic predictors for use in individualising drug treatment for patients, particularly early on in the disease course. We hereby discuss the perioperative management of such a patient who came to our set-up for bipolar haemiarthroplasty.

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This paper is an exhaustive review about the main aspects of oxaliplatin induced peripheral neuropathy, focus in clinical features, treatment, prevention strategies and future approach. This action was unaffected by endothelium and mediated predominantly by ETA receptors.

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Addressing educational inequalities, promoting safe sleep practices, and reducing smoking among Native Hawaiian mothers would help to eliminate excess infant mortality. Adrenalectomy, but surprisingly not RU38486, suppressed the fasting-induced increase in GS activity and expression. Review of the literature concerning the relationship between atypical femoral fractures and antiresorptive drugs (bisphosphonates), identifying the pathogenesis of this adverse event.

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Since the introduction of percutaneous transluminal coronary angioplasty, restenosis has remained the most challenging problem facing interventional cardiologist. After HKC cells were stimulated with TGF-beta1 (5 microg/L), the mRNA levels of PAI-1 and fibronectin were measured by RT-PCR. Correlates of physical activity (PA) are hypothesized to be context and behaviour specific, but there is limited evidence of this in young children.

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The effect of the selected compounds on Plasmodium berghei in vivo was assessed using standard methods. In addition, the involvement of ASICs in mediating proton stimulation of CGRP was investigated using the potent and selective ASIC3 inhibitor APETx2. In order for caregivers to be effective partners in care, a balance needs to be struck between valuing their involvement in providing care for a patient and not overburdening them.

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Conditions that were found to promote successful implementation of primary health care are outlined, together with features of effective primary health care systems that help create more equitable health services and health outcomes. E2F-1 may be involved in regulating multiple signaling pathways in reversing MDR, suggesting that E2F-1 may represent a novel target for gastric cancer therapy.

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Treatment participation might improve if desire for self-reliance and the preference for informal help are considered, and perceived ineffectiveness of treatment and stigmatisation are publicly addressed. Comparative observation on acupuncture-moxibustion and western medication for treatment of sudden deafness Knockdown of IoTis11 with a translation-blocking morpholino oligonucleotide causes a very similar set of phenotypes as ablation of 3a and 3b, showing that translation of this transcript is required for normal development of 3a and 3b.

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The objective of the present study was to examine the effect of monophosphoryl lipid A on endothelial function and ischemia-reperfusion-induced myocardial injury in the rats treated with LDL. Moreover, it also facilitates the selective accumulation and controlled release of the drug at inflamed sites of the colon. Behavior of animals was assessed during the active and passive avoidance learning, as well as in the open-field test. They are part of the pheromone signaling cascade in both ascomycetes and basidiomycetes, which is crucial for the recognition and fusion of cells of opposite mating type. Comparison of mesiodistal tooth crown diameters and arch dimensions between modern Mongolians and Japanese.

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Disturbed resting functional inter-hemispherical connectivity of the ventral attentional network in alpha band is associated with unilateral spatial neglect. Documentation of severe pain, opioid doses, and opioid-related side effects in outpatients with cancer: a retrospective study. There was a significant treatment effect on the recovery of colony-forming units in milk samples when comparing the control sample with handling regimens 1 through 7.

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Concentrations of total protein, albumin, alpha-1 globulin, beta globulin, gamma protein, immunoglobulin in class A (IgA), G (IgG), M (IgM) and E (IgE), creatinine kinase (CK), creatinine kinase MB (CK-MB), CRP and fibrinogen were quantified. The application of the methods is illustrated on images of XTC cells. We hypothesized that the assisted maintenance of head extension would reduce the frequency of direct contact between the laryngoscope blade and the maxillary incisors during tracheal intubation. The heat shock response, which is characterized by the induction of heat shock proteins, is known to affect the ability of tumour cells to cope with potentially adverse conditions such as hypoxia, glucose starvation and cytotoxic immune reactions.

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Influence of olfactory innervation on neurogenesis in the developing olfactory bulb of the frog, Xenopus laevis. A follow-up report was subsequently sent every 6 months requesting information on changes in prophylaxis, antiretroviral drugs, new AIDS-defining events, and CD4 cell count results. Persistence of this association after adjustment for estimated prior cognitive ability suggests that the association may be attributable, at least in part, to an effect of hypoglycaemia on age-related cognitive decline. Across both studies, no age differences were found regarding the frequency of involuntary episodic memories, whereas older adults showed slower (Study 1) and less frequent (Study 2) voluntary remembering compared with younger adults.

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