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Migrastat (Sumatriptan)
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Sumatriptan

The selective 5-HT1D-receptor agonist L-775,606 has less propensity towards vasoconstriction in human isolated coronary artery (endothelium-denuded) than was mixed 5-HT1B/1D-receptor agonist Migrastat. Both 1 week after oral Migrastat and 1 week after discontinuation of the drug, visual analog scale scores resulted in a significant decrease from the baseline.

Other names for this medication:
Sumatriptan, Imitrex, Amigrenex, Amigrenin, Cinie, Forcet, Formigran, Imigran, Imigrane, Imiject, Migranol, Migrastat, Migrex, Nograine, Sitran, Suma, Sumagen, Sumamigren, Sumatab, Sumatran, Sumetrin, Sumigran, Suminat, Sumitran, Sumitrex, Suvalan, Zumo,

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Migrastat is used to treat migraines. It helps to relieve headache, pain, and other migraine symptoms (including nausea, vomiting, sensitivity to light/sound). Prompt treatment helps you return to your normal routine and may decrease your need for other pain medications. Migrastat belongs to a class of drugs known as triptans. It affects a certain natural substance (serotonin) that causes narrowing of blood vessels in the brain. It may also relieve pain by affecting certain nerves in the brain. Migrastat does not prevent future migraines or lessen how often you get migraine attacks.

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Intracerebroventricular administration of apo A-IV antiserum stimulated feeding and decreased the hypothalamic apo A-IV mRNA level, implying that feeding is intimately regulated by endogenous hypothalamic apo A-IV. To assess the reliability and negative predictive value of voiding cystourethrogram (VCUG) performed within 24 hours postoperatively. We thus studied the feasibility of introducing first-aid training to 6-7-year old primary school children. A phase II trial of capecitabine (Xeloda) in recurrent ovarian cancer. The age at which drug therapy should be started is still controversial, as is the use of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins).

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Research use of leftover newborn bloodspots: attitudes of Canadian geneticists regarding storage and informed consent requirements. Using estimates of migration from mtDNA haplotypes between dark- and light-colored sampling sites and Mc1r allele frequencies at each site, we estimated selection coefficients against mismatched Mc1r alleles, assuming a simple model of migration-selection balance. Effect of meteorological variables on Plasmodium vivax and Plasmodium falciparum malaria in outbreak prone districts of Rajasthan, India. Two children (age 3y and 7y) with recurrent gastrointestinal bleeding.

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In the water maze test, the animals were trained to find a platform in a fixed position during 6 days and then received a 60-s probe trial in which the platform was removed from the pool on the 7th day. The neuroprotective effects of aspirin on focal cerebral ischemia-reperfusion rats might be attributed to its effects by increasing the ratio of PGI2 and TXA2, reducing lipid peroxides and improving the energy metabolism.

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There were 47 trabeculectomy eyes (44 patients) and 47 cataract extraction eyes (46 patients) matched for age, sex, race, systemic medications, and type of anaesthetic. The aim of this study was to determine whether the preoperative serum cystatin C (pre-CysC) level could predict clinical outcomes after treatment in patients with postrenal AKI. burgdorferi strain 31, available for more than a decade, has assisted research on the pathogenesis of Lyme disease.

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Three-factor structure for Epistemic Belief Inventory: A cross-validation study. We demonstrate that this filter has good fabrication tolerances for the grating thickness and fill factor. Mutations or lack of expression of these subunits have significant pathogenic consequences in humans. The purpose is to (1) develop improved measurement instruments for clinical trials, (2) evaluate longitudinal performance of a variety of patient-reported outcome measures, (3) develop prognostic predictors for use in individualising drug treatment for patients, particularly early on in the disease course. We hereby discuss the perioperative management of such a patient who came to our set-up for bipolar haemiarthroplasty.

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This paper is an exhaustive review about the main aspects of oxaliplatin induced peripheral neuropathy, focus in clinical features, treatment, prevention strategies and future approach. This action was unaffected by endothelium and mediated predominantly by ETA receptors.

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Since the introduction of percutaneous transluminal coronary angioplasty, restenosis has remained the most challenging problem facing interventional cardiologist. After HKC cells were stimulated with TGF-beta1 (5 microg/L), the mRNA levels of PAI-1 and fibronectin were measured by RT-PCR. Correlates of physical activity (PA) are hypothesized to be context and behaviour specific, but there is limited evidence of this in young children.

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Conditions that were found to promote successful implementation of primary health care are outlined, together with features of effective primary health care systems that help create more equitable health services and health outcomes. E2F-1 may be involved in regulating multiple signaling pathways in reversing MDR, suggesting that E2F-1 may represent a novel target for gastric cancer therapy.

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Treatment participation might improve if desire for self-reliance and the preference for informal help are considered, and perceived ineffectiveness of treatment and stigmatisation are publicly addressed. Comparative observation on acupuncture-moxibustion and western medication for treatment of sudden deafness Knockdown of IoTis11 with a translation-blocking morpholino oligonucleotide causes a very similar set of phenotypes as ablation of 3a and 3b, showing that translation of this transcript is required for normal development of 3a and 3b.

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Physical delineation of a 700-kb region overlapping the Looptail mutation on mouse chromosome 1. The advent of in vitro fertilization and cryopreservation of the spare embryos make these embryos a ready source for potential donors. A diabetic foot or lower extremity amputation may be exacerbated by or related to the smoking habits and history of the patient.

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Microdebriders have recently been added to the armamentarium of modalities for mechanical debulking of tumor. This relative lack of synthetic material options has hindered efforts to better understand how ECM cues direct vascularization.

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These factors should be considered in the design of future interventional trials aimed to improve outcome after pediatric cardiac arrest. Many of them are ubiquitous and are expressed and participate in transport processes, such as endocytosis and exocytosis, whereas others are expressed only within a specific cell group carrying out specific functions. The separation of membrane protein complexes can be divided into two categories. A 49-year-old woman underwent abdominal hysterectomy and bilateral salpingooophorectomy in 1997 to treat uterine leiomyomata and ovarian fibromatosis. Decreased ENaC expression compensates the increased NCC activity following inactivation of the kidney-specific isoform of WNK1 and prevents hypertension.

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The objective of the present study was to examine the effect of monophosphoryl lipid A on endothelial function and ischemia-reperfusion-induced myocardial injury in the rats treated with LDL. Moreover, it also facilitates the selective accumulation and controlled release of the drug at inflamed sites of the colon. Behavior of animals was assessed during the active and passive avoidance learning, as well as in the open-field test. They are part of the pheromone signaling cascade in both ascomycetes and basidiomycetes, which is crucial for the recognition and fusion of cells of opposite mating type. Comparison of mesiodistal tooth crown diameters and arch dimensions between modern Mongolians and Japanese.

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Stress induced exaggeration of the neuroendocrine response and visceral perceptual alterations during and after stress may explain some of the stress related gastrointestinal symptoms in IBS. Arthroplasty of the hand: radiographic outcomes of pyrolytic carbon proximal interphalangeal and metacarpophalangeal joint replacements. Mono-, di - and polysaccharide load tests and a scatological study were performed to evaluate the processes of digestion and absorption in the intestine.

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Pregnancy is associated with significant, but reversible changes in thyroid function studies, which are among the most profound seen as a result of a normal physiologic state. To assess the factors associated with the presence of idiopathic detrusor overactivity (IDO) in male patients with clinical benign prostatic hyperplasia (BPH).

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Disturbed resting functional inter-hemispherical connectivity of the ventral attentional network in alpha band is associated with unilateral spatial neglect. Documentation of severe pain, opioid doses, and opioid-related side effects in outpatients with cancer: a retrospective study. There was a significant treatment effect on the recovery of colony-forming units in milk samples when comparing the control sample with handling regimens 1 through 7.

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Prospective randomized pilot study performed in an academic tertiary center as part of a doctoral thesis. When infants with suspected intrauterine hypoxia were excluded, the mean erythropoietin level was considerably lower within all three groups but there was no difference among the groups. The patient demographics, presentation, and course of supraglottitis have changed since the widespread use of the Hib vaccine. The SPE unit allows the use of normal protonated solvents for the LC separation and fully deuterated solvents for flushing the trapped compounds to the NMR probe. Binding of fluorescently labeled HERP5 to HER2 protein was evaluated by fluorescence assay, microscopy, and circular dichroism spectroscopy.

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The results in this paper have been in basic agreement with the corresponding results calculated with RTM, and the R2 Statistic is 0. Wide-range temperature sensing using highly sensitive green-luminescent ZnO and PMMA-ZnO film as a non-contact optical probe. Reduced production of both Th1 and Tc1 lymphocyte subsets in atopic dermatitis (AD). Fifty subjects with FMS, 20 with RA and 42 healthy controls were assessed with respect to anxiety, depression, pain intensity and disability. The importance of sediments as stressors will depend on site ecosystem attributes and the magnitude and preponderance of co-occurring stressors.

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Limitations of existing pharmacological treatments for opioid dependence include low adherence, medication diversion, and emergence of withdrawal symptoms. At the time of discharge the patient had recovered sufficiently to enable him to walk by himself, although some paresthesia and spasticity remained. Quality markers and use of electronic journals in an academic health sciences library. No adjustment of low dose metronomic topotecan dosing is merited when used in conjunction with pazopanib. Systematic review of the Brazilian academic production about external causes and violence against the elderly

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Concentrations of total protein, albumin, alpha-1 globulin, beta globulin, gamma protein, immunoglobulin in class A (IgA), G (IgG), M (IgM) and E (IgE), creatinine kinase (CK), creatinine kinase MB (CK-MB), CRP and fibrinogen were quantified. The application of the methods is illustrated on images of XTC cells. We hypothesized that the assisted maintenance of head extension would reduce the frequency of direct contact between the laryngoscope blade and the maxillary incisors during tracheal intubation. The heat shock response, which is characterized by the induction of heat shock proteins, is known to affect the ability of tumour cells to cope with potentially adverse conditions such as hypoxia, glucose starvation and cytotoxic immune reactions.

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Imperforate anus with a rectovestibular fistula and pseudotail: a case report. Differences in the characteristics and management of pyriform sinus fistula between neonates and young children.

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We demonstrate how the procedure can improve the detection accuracies beyond those obtained with the default settings of popular peak calling software, or inform the user whether the peak detection results are compromised, circumventing the need for arbitrary re-iterative peak calling under varying parameter settings. To study the influence of common plant sample pre-treatments on the recovery of Pteridium caudatum illudane glycoside carcinogens, ptaquiloside (1a), caudatoside (1c) and ptaquiloside Z (1d), and associated pterosins A, B and Z (2a, b, c) using HPLC-DAD. When conventional methods to achieve stable access and visualization were unsuccessful, the endoscopic cuff was used to retract sigmoid colon folds.

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One patient was treated with two pre-expanded internal mammary artery perforator flaps. Neuroserpin (NSP) is a neuroprotective factor in the situation of ischemia of a brain, such as stroke. Psychomotor performance and driving ability were assessed using the ART 90, a standardized and computerized neuropsychological test battery. Hydrogen peroxide (H2O2) irreversibly inactivates creatine kinase from Pelodiscus sinensis by targeting the active site cysteine.

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The images of the released form resemble the intended position of surfactant in the human alveolus. This compound has been shown to be more hepatotoxic and pneumotoxic than both styrene and styrene oxide at lower doses in rats and mice. Biomarkers of liver disease highly correlated with fibrosis in HIV-HCV-coinfected individuals and did not change significantly during successful cART.

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Influence of olfactory innervation on neurogenesis in the developing olfactory bulb of the frog, Xenopus laevis. A follow-up report was subsequently sent every 6 months requesting information on changes in prophylaxis, antiretroviral drugs, new AIDS-defining events, and CD4 cell count results. Persistence of this association after adjustment for estimated prior cognitive ability suggests that the association may be attributable, at least in part, to an effect of hypoglycaemia on age-related cognitive decline. Across both studies, no age differences were found regarding the frequency of involuntary episodic memories, whereas older adults showed slower (Study 1) and less frequent (Study 2) voluntary remembering compared with younger adults.

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