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Kespirona (Spironolactone)
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Spironolactone

Kespirona is used to treat high blood pressure and heart failure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. It is also used to treat swelling (edema) caused by certain conditions (such as heart failure, liver disease) by removing excess fluid and improving symptoms such as breathing problems. This medication is also used to treat low potassium levels and conditions in which the body is making too much of a natural chemical (aldosterone). Kespirona is known as a "water pill" (potassium-sparing diuretic).

Other names for this medication:
Spironolactone, Aldactone, Aldactazide, Aldactazine, Aldazida, Aldazide, Aldozone, Alexan, Alizar, Carpiaton, Espirone, Espironolactona, Expal, Kespirona, Lanx, Letonal, Osiren, Osyrol, Practon, Prilactone, Spiractin, Spiresis, Spirix, Spiroctan, Spirolang, Spirolon, Spiron, Spirono, Spironolacton, Spironolactona, Spironolakton, Spironolattone, Spirotone, Verospiron, Xenalon,

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Kespirona comes as a tablet and suspension (liquid; Carospir) to take by mouth. It usually is taken once or twice a day. Take Kespirona suspension consistently either with food or without food each time. Take Kespirona at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Kespirona exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Shake the oral suspension well before each use to mix the medication evenly.

Your doctor may start you on a low dose of Kespirona and gradually increase your dose.

Kespirona tablets and suspension release the medication differently in your body and cannot be substituted for one another. Only take the Kespirona product prescribed by your doctor and do not switch to a different Kespirona product unless your doctor says that you should.

Kespirona controls high blood pressure, edema, heart failure, and hyperaldosteronism but does not cure these conditions. It may take about 2 weeks or longer before the full effect of Kespirona occurs. Continue to take Kespirona even if you feel well. Do not stop taking Kespirona without talking to your doctor.

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Alteration of cellular behavior and response to PI3K pathway inhibition by culture in 3D collagen gels. Participants in a single-day spearfishing competition were recruited. Magnetoresistance of a periodic superconducting network near Tc. Liver transplantation for hepatocellular carcinoma validation of present selection criteria in predicting outcome.

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Unfortunately, the low treatment and control rates, combined with the high prevalence of both conditions, still contribute to the high burden of cardiovascular disease in Western countries. They have the gastrointestinal adverse effects such as erosions and ulcers in stomach and small intestine. Case-control study comparing PG to healthy control (HC) subjects.

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This study was planned to compare renal function between normal-weight and overweight children. The purpose of this study was to test the hypothesis that the immunohistochemical expression of ERCC1 and RASSF1A would predict both response to and survival after docetaxel and cisplatin combination chemotherapy in inoperable or recurrent head and neck squamous cell carcinoma.

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Certain post-operative outcomes were compared between the three groups as well as between elective and emergency operations. Chronic kidney disease (CKD) patients on dialysis are prone to vitamin D insufficiency despite oral vitamin D supplementation. This is often due to the disruption of brain networks that support cognition. Severe mental illness is associated with long-lasting symptoms and various impairments including individual, social and occupational aspects.

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The significance of the test methods in coordinating the theories of focal infection We highlight the importance of recognizing AKI in asphyxiated newborns undergoing therapeutic hypothermia, along with the potential benefits of early recognition. We show that the ubiquitous trafficking protein ADP Ribosylation Factor 1 (ARF1) and the hemocyte-specific endosomal regulator Asrij differentially regulate humoral immunity.

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albopictus fed with a DENV-2 infectious blood-meal which showed positive signals in the lateral lobes of infected samples, with no significant signal in uninfected mosquitoes. Sexually transmitted infections are diagnosed in men seen at urgent care centers more often when clients present with relevant symptoms. These results suggest that, besides host-driven selective forces, both the live feed and the surrounding rearing environment contribute to shaping the microbiome of farmed gilthead sea-bream larvae, and that a differential establishment of host-associated bacteria takes place during larval development. Although the mechanistic details for this phenomenon are still missing, we claim that these new evidences are highly relevant for the origin of the first functional cells in primitive times. A greater muscle protein synthesis up-regulation associated with a stimulation of the mTOR signalling pathway was indeed recorded but it remained inefficient to prevent the loss of muscle in the non-immobilized limb.

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During inflation, atelectatic regions may exhibit alveolar recruitment accompanied by prolonged filling with air in contrast to regions with already open alveoli with a fast increase in regional aeration. Hepcidin synthesis is suppressed by erythropoiesis and iron deficiency and upregulated by iron overload and inflammation. These results suggest that APOE-epsilon4 carriers may have a greater severity of depressive symptoms than non-carriers.

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This process of development and maintenance of the lexicon is described. Beyond HDL cholesterol, a new notion is the functionality of HDL particles. WITHDRAWN: Is microcephaly a so-far unrecognized feature of XYY syndrome? Can nuclear magnetic resonance (NMR) spectroscopy reveal different metabolic signatures for lung tumours?

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Re: Neostigmine and Functional Endoscopic Sinus Surgery - ocular side-effects of other general anaesthetic agents. The expressions of both c-fos and c-myc were not statistically significant between VEGF positive and negative patients.

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Inhalation uptake is an important pathway of exposure, especially with respect to domestic radon exposure. Molecular biology of sporadic gastric cancer: prognostic indicators and novel therapeutic approaches. These activities focused on Local and National Influenza Surveillance Systems, the regional Pandemic Plan, vaccination strategies for seasonal and pandemic influenza, and the communication of data from monitoring programs (sentinel physicians--syndromic surveillance).

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One patient showed gradual disappearance of nephrotic syndrome and proteinuria during the 16-month follow-up. These results suggest that the nicotinic cholinergic system and the A/T polymorphism modulate ethanol withdrawal. Based on the results hemiester analogs increased water solubility of the drug up to about 3 and 8 folds, respectively. Decision tree analysis was used to calculate the cost-effectiveness of a combined FNA/MIBI investigative strategy compared to the BTA guidelines.

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Minnesota, Hawaii, and Nebraska, among the responding states, currently reimburse for telerehabilitation. People with convulsive epilepsy who were previously untreated (or on irregular treatment) were commenced on regular treatment with phenobarbital. The Bunyaviridae constitute the viral family that he studied the most.

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Rt inhibition is likely to act in concert with actions of neuromodulators in optimizing thalamic temporal signaling of high-frequency whisker movements. Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. We show that quantum frequency conversion (QFC) can overcome the spectral distinguishability common to inhomogeneously broadened solid-state quantum emitters. We demonstrate that orbital degrees of freedom in frustrated lattice systems lead to a narrowing of topologically nontrivial bands. To elucidate optimal dose of rhEGF on CCRT-induced mucositis, various concentrations (0.04-3 mg/kg) of rhEGF were injected for 3 days.

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Sarcoidosis is a systemic granulomatous disease of unknown etiology that involves many organs, occasionally mimicking malignancy. Abstracts of the 6th Congress of the European Society for Sexual Medicine. Orthogonal radiographs were taken immediately postoperatively and after wound healing to visualize the location and number of hemoclips or metallic staples. All pure mycotoxins exposed to CAPP were degraded almost completely within 60 s.

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Outer Plexiform Layer Structures Are Not Altered Following AAV-Mediated Gene Transfer in Healthy Rat Retina. Prevalence of GB virus type C/hepatitis G virus RNA and anti-E2 among blood donors in Southeastern France. The activation cycle of Rab GTPase Ypt32 reveals structural determinants of effector recruitment and GDI binding. Targeted Ultrasound-Triggered Phase Transition Nanodroplets for Her2-Overexpressing Breast Cancer Diagnosis and Gene Transfection.

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Protein quality control guided by ER chaperons is most essential for full biological activity. When more than four cartilages are removed, the chest is stabilized by articulated bars made using cylindrical fragments obtained by the division of the removed costal cartilages.

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Through the generation of these simple, repeatable models, this work aims to develop a modelling framework that is suitable for the study of biological systems and clinical use. Thirty-eight patients (14 with low-grade and 24 with aggressive histologically proven NHL) were studied prospectively. Long columns (1 and 2 meters) and an in situ lysimeter (4 m) were used to allow investigation of larger-scale transport under controlled conditions. Correlation between filling defect patterns on urography and pathologic staging of ureteral transitional cell carcinomas. The prognostic significance of angiogenic markers remains controversial.

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The results represent a more precise prediction with less mean and variance of error. The Z4A5 infusion induced a dose-dependent reduction in CFR frequency, which returned to baseline levels after the termination of the infusion at low doses. Thirty-one of the patients who had survived for more than 5 years were compared with 56 patients who had survived for less than 5 years. The assay also enables detection of a minority population of drug resistant Mtb, a clinically relevant scenario referred to as heteroresistance. Significantly, the Suzuki-Miyaura coupling reactions could be efficiently performed in an environmentally friendly aqueous solution with no need for further additives.

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As proof of concept, we performed kinesin-1 gliding motility assays with antibody-conjugated microtubules and demonstrated the highly sensitive detection of fluorescent protein analyte down to 0.1 pM in microliter sample volumes. Overall, the present study represents an important extension of previous laboratory NSSI studies and provides a fertile foundation for future studies aimed at understanding why people engage in NSSI. The results are consistent with the established fact that AVP secretion is a function of plasma osmolality.

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Professional performance at the highest level can only be expected from teams which regularly participate in team training for critical situations. Functional segregation and emerging role of cilia-related cytosolic carboxypeptidases (CCPs).

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A complex multiple aquifer system affected by a contaminated site and exposed to tidal effects was investigated to develop the hydrogeological conceptual model of the study case. Six-year results of spironolactone and testolactone treatment of familial male-limited precocious puberty with addition of deslorelin after central puberty onset. The erbB family of cell surface receptor proteins consists of four members, all of which play a role in the development and growth of the normal breast. These two hypotheses were confirmed after factor-analysing the internal structure of the three sections of the questionnaire. To explore the inhibitory effect of different sources, different concentrations of Mannose-binding lectin (MBL) on human cytomegalovirus infection of human MD-DC cells.

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The overall catabolic activity of alpha-MSH is smallest in the middle-aged and highest in the oldest group. These results reveal genetic differences in the persistence of ethanol withdrawal-induced hypo-locomotion. In the present study, we examined the lysophosphatidic acid (LPA) pathway in the ovine uterus during the estrous cycle and early pregnancy.

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In vitro antibacterial activity of some antihistaminics belonging to different groups against multi-drug resistant clinical isolates. Impact of tissue heterogeneity on noninvasive near-infrared glucose measurements in interstitial fluid of rat skin. Recently, SOX2 expression has also been reported in adult stem cells (ASCs), but the role of SOX2 in ASCs remains unknown. Results point out the limited and insufficient stigma-reducing components of direct-to-consumer prescription drug websites.

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Gene flow from cultivated rice (Oryza sativa) to its weedy and wild relatives. These findings suggest that spinal cord reorganization mitigates the typical response to load in people with chronic SCI.

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Scattering lengths and effective ranges for He-He and spin-polarized H-H and D-D scattering. After 2005, most patients received weekly cisplatin (Q1) (40 mg/m intravenously weekly for 7 wk of RT) and intensity-modulated radiotherapy (70 Gy, 35 fractions). Intraocular pressure measurements during flap preparation using 2 femtosecond lasers and 1 microkeratome in human donor eyes.

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To provide growth and sexual maturation reference data for Moroccan children living in The Netherlands and to compare them with the reference data of children of Dutch origin. We propose a compact optical system made up of a thin collimator and a free-form lens array to provide the uniform illumination of various-shape regions. Hyaluronidase as an agent facilitating intramuscular urography in children. Research suggests that women with bulimia nervosa can be classified into dietary and dietary-depressive subtypes and that the latter show greater eating pathology, social impairment, comorbidity, and treatment nonresponse.

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Even in elderly patients with advanced cSCC, cetuximab was efficacious and well-tolerated. Treatment with TPT-benzimidazolethiol in HeLa cells is accompanied by the up-regulation of Bak at the transcriptional level, resulting in the release of cytochrome c and Smac/DIABLO from mitochondria to cytosol and, subsequently, the activation of procaspase-9, -3 and PARP, suggesting that TPT-benzimidazolethiol induced-apoptosis signaling is by an intrinsic mitochondrial pathway. Review of recent studies and issues regarding the P300-based complex trial protocol for detection of concealed information. Recent studies offer insight into generational factors that should be considered in strategies to promote stable staffing in healthcare organizations. Therapy by sugars, activators and adjuvants of glucide metabolism in neurology, neuropsychiatry and in several other branches of medicine

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Abnormal Liver Tests and Persistent Lactic Acidosis in an 18-Year-Old Woman. These two domains of competency are discussed with respect to their significance in both CAM and conventional healthcare practices.

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However, CGH to metaphase chromosomes can provide only limited resolution at the 5-10 Mb level. In this review we discuss the most current and up to date understanding of the possible signaling mechanisms by which caloric restriction, as well hormetic caloric restriction-mimetics compounds by activating vitagenes can enhance defensive systems involved in bioenergetic and stress resistance homeostasis with consequent impact on longevity processes. This is the first report of the antibacterial activity of Columbian plants against NG. Therefore, we think that this combined technique offers the best chance for an optimal esthetic and functional rehabilitation of patients with these malformations.

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Translesion-synthesis DNA polymerases participate in replication of the telomeres in Streptomyces. Enoxaparin sodium-induced bullous pemphigoid-like eruption: a report of 2 cases.

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Hoechst 33258 staining and the Annexin-V FITC assay demonstrated that paclitaxel synergized with jesridonin in a stronger induction of apoptosis than treatment with paclitaxel or jesridonin alone. Our study documented a spontaneous model of recurrent uveitis in the rat, which should assist us in the study of disease pathogenesis and the design of specific therapy. Many Gram-negative intestinal pathogens produce AraC-like proteins that control the expression of genes required for infection.

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For patients with AS or RA, such strategies will be critically dependent on further research that defines individual risk factors and need for interventions. The number of taxa within functional groups and conservation concerns are botanical issues that deserve further research.

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Nurses may find themselves in hospitals affected by a disaster, awaiting a surge of patients while supplied with only limited resources. No subject had detectable urine DMPS or increased urine mercury excretion after TD-DMPS. Interaction between surface shape and intra-surface viscous flow on lipid membranes.

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We also found that tele-ICU physicians can make poor care decisions leading to medication errors if they lack patient-related information. To evaluate, we surveyed separate samples of adults in HAC communities before and after the interventions and compared responses to identical survey questions asked of adults living in Alberta in two waves of the Canadian Community Health Survey (CCHS).

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Lipid rafts are membrane microdomains that play important role in life cycle of microbes. Surface-modified poly(lactide-co-glycolide) nanospheres for targeted bone imaging with enhanced labeling and delivery of radioisotope.

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This study applied the AIDS case-finding algorithm to paid Medicaid claims linked to New Jersey AIDS surveillance data and assesses its sensitivity across subgroups of patients. Optimal management of phenylketonuria: a centralized expert team is more successful than a decentralized model of care.

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Since, probiotics are now widely used in both medical (such as cancer risk reduction, gastrointestinal tract health, and urinary tract health) and dental specialties (reduction in caries development, in achieving periodontal health, reducing oral malodor, etc.), a thorough understanding of their risks and benefits are essential. Tacrolimus may be associated with lower osteonecrosis rates after renal transplantation. Recent investigations have shown that hair follicles constitute a niche for this cell type, but their localization and their definite function in non-follicular skin remains largely unknown. The objective of this experiment was to investigate regional brain neurotransmitter alterations caused by EA.

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Serum FGF23 concentrations remain increased in long-term kidney graft recipients, even in the early stages of CKD. The present study used the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride (DSP4) to reduce brain levels of NE in juvenile males. Presumed PAIS, larger infarct volume, and comorbid epilepsy negatively influenced the performance on attention and executive functioning measures.

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Analysis of splice variants of the immediate-early 1 region of human cytomegalovirus. Luciferase assay was used to confirm the effects of leptin and STAT3 phosphorylation inhibitor on the transcriptional activity of hTERT promoter. The genes involved in the phenylpropanoid pathway and flavonoid biosynthesis were also up-regulated. Herceptin-decorated salinomycin-loaded nanoparticles for breast tumor targeting. Platonin mitigates acute lung injury in haemorrhagic shock/resuscitation rats.

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Binding of phage Phi29 architectural protein p6 to the viral genome: evidence for topological restriction of the phage linear DNA. However, the ideal structure, method and timing of telephone follow-up as well as the skills required to carry out such care over the phone are often not considered and have not been articulated. Both channels exhibit unique properties compared with their mammalian orthologues that support electrosensory functions: structural adaptations in CaV1.3 mediate a low-voltage threshold for activation, and alterations in BK support specifically tuned voltage oscillations. The two rotors are confined in a plane and move along circles driven by active forces. The new scaled partial covariance density provides additional information on the direction and the type, excitatory or opiren flas 15 mg medicamento inhibitory, of the connectivities.

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Pre- meden inmed treatment cageri and perioperative factors affecting infection after living donor liver transplantation. Beet western yellows virus (BWYV) is a Polerovirus that relies on the aphid Myzus persicae for its transmission, in a persistent-circulative mode.

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Drug hypersensitivity and human leukocyte antigens of the major histocompatibility complex. However, long-term exposure to some unpalatable tastants increases acceptance of these foods. Such health-related risk factors may impact on the course of asthma and on overall health. Besides to pathogenic proprieties, apoptosis also participates in the innate defense trough restriction of intracellular pathogens propagation. Does the cyclophosphamide induced pulmonary toxicity from radiation amount of filler content in sealants used to prevent decalcification on smooth enamel surfaces really matter?

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In this chapter a number of single treatments are discussed with respect to their multiplicity of action. In the present work, the proton selective relaxation rate and the affinity index were used to investigate the interaction of CA with human serum albumin and bovine serum albumin under the same buffer conditions. Assessment of intracranial blood flow velocities using a computer controlled vasoactive stimulus: a comparison dicloflex 50 mg toothache after filling between phase contrast magnetic resonance angiography and transcranial Doppler ultrasonography. This in vitro study demonstrates strong immunosuppressive activity by both chimeric and humanized MoAbs against CD25.

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Drosophila TRF2 and TAF9 regulate lipid droplet size and phospholipid fatty acid composition. Seven of the key elements of this improved information infrastructure are clinical volfenac gel side effects trial registries, research reporting standards, systematic reviews, organizations that support the production of systematic reviews, the indexing of clinical intervention research in MEDLINE, clinical search filters for MEDLINE, and point-of-care decision support information resources. Combined use of KY02111 and WNT signaling modulators produced robust cardiac differentiation of hPSCs in a xeno-free, defined medium, devoid of serum and any kind of recombinant cytokines and hormones, such as BMP4, Activin A, or insulin. Although a complete cell division was not observed, the results provided conclusive evidence that cell cycle-related events in postmitotic cardiomyocytes could be triggered by genetic intervention downstream of the G1/S checkpoint. We report the case of a 31-year-old woman affected by Melkersson-Rosenthal syndrome, who has been successfully treated with lymecycline, after variable results with steroids alone or combined with antihistamines, sulphasalazine and clofazimine.

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Racial differences in discrimination experiences and responses among minority substance users. To identify linear peptide homing to non-small cell lung cancer (NSCLC) tumor cells using ex vivo phage display method. Latent transition analysis was used india tv aap ki adalat narendra modi 12 april to establish classes of bullying, victimization, bully-victimization, and uninvolvement. The extent of surgical therapy depends on the malignant potential of the primary tumor. Here we will discuss the similarities between NRF2 and p53 and review evidence that p53 might be exploited by cancer cells to gain protection against oxidative stress, as is the case for NRF2.

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Results suggest that rs3778150 may be causally related to alcohol use phenotypes, and could potentially account for previously observed associations of rs1799971 with substance use phenotypes. Maggot therapy for wound care in Iran: a case series of the first mhra simvastatin vs atorvastatin 28 patients. Clinical role of circulating Epstein-Barr virus DNA as a tumor marker in lymphoepithelioma-like carcinoma of the lung.