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Afungil (Fluconazole)

Afungil is a synthetic compound known as a bis-triazole. It was first used in patients 1994/95 and licensed for use in 1990. It went off patent in 2003. It works by inhibiting the production of ergosterol, a central chemical in the cell walls of fungi. The drug is available as a capsule, oral suspension and intravenous infusion. A typical dose for oral thrush is 100mg per day. The typical dose for vaginal thrush is a 150mg per day. For the prevention of fungal infections in leukaemia, doses from 50-400mg per day have been used and studied. Most authorities recommend between 100 and 400mg. For the treatment of candidemia and other serious Candida infections a minimum dose of 400mg per day (after a loading dose of 800mg) is recommended with increased doses in patients on haemofiltration and/or rifampicin (see below). Some authors have suggested that 800mg is superior for candidaemia, but the data is not compelling. For the treatment of cryptococcal meningitis after amphotericin B, a minimum of 400mg per day initially is used until the patient is stable and then typically 200mg per day. Much larger doses e.g. 800-1200mg per day should be used as an alternative primary regimen (preferably with flucytosine) or for patients failing therapy. Larger doses such as 800-1200mg per day have been used for coccidioidal meningitis. Almost all other treatments have been for 100-400mg per day. Reduced doses may be appropriate in severe renal dysfunction.

Other names for this medication:
Fluconazole, Diflucan, Afumix, Afungil, Batacan, Candidin, Diflazon, Difluzol, Difluzole, Dizole, Dofil, Duracan, Efac, Elazor, Exomax, Farzul, Fluc, Flucomed, Flucon, Fluconapen, Fluconazol, Flusenil, Flutec, Fluvin, Fluzol, Fluzole, Fluzone, Forcan, Govazol, Honguil, Ibarin, Kifluzol, Lavisa, Logican, Lucon, Medoflucon, Novacan, Omastin, Ozole, Ponaris, Rifagen, Sacona, Stabilanol, Syscan, Ticamet, Trican, Triflucan, Trizol, Uzol, Varmec, Zemyc, Zoldicam, Zolen, Zoloder, Zucon,

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Afungil is used to treat vaginal yeast infections. It works by stopping the growth of common types of vaginal yeast (fungus). This medication belongs to a class of drugs called azole antifungals.

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On the other hand, the soft X-ray imaging system is under construction to measure beam sizes with negligible diffraction-limited error. The pseudocapsule in hepatocellular carcinoma: correlation between dynamic MR imaging and pathology. This reprogramming of DNA methylation takes place firstly on fertilization in the zygote, and secondly in primordial germ cells (PGCs), which are the direct progenitors of sperm or oocyte. Random peptide libraries were genetically inserted into three loops to create hybrid enzymes with binding sites for Mabs. Average-KR schedule benefits generalized motor program learning.

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The current challenge in CTC research is the acquisition of useful clinical information from the multitude of high-throughput studies. The aim of this study was to compare the shear bond strength between Ni-Cr alloy specimens bonded to air-abraded Ni-Cr, bur-abraded Ni-Cr, etched ceramic and etched enamel substrates using the resin cements RelyX ARC or Enforce.

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The main mechanism underlying such a phenomenon consists in improved leptin signaling through the Ob-Rb leptin receptor isoform, which seems to consequently lead to overexpression of brain-derived neurotrophic factor (BDNF) and thyrotropin-releasing hormone (TRH). Insufficient intake of calcium, while fully covering the demand for phosphorus, resulted in improper ratio these minerals in the diet (0.62 at the recommended, of 1). Thymoquinone induces mitochondria-mediated apoptosis in acute lymphoblastic leukaemia in vitro. The quality of fixation can be materially improved by buffering the OsO(4) solutions at pH 7.3-7.5, The acetate-veronal buffer appeared to be the most favorable of the buffers tested, Because of these findings, 1 per cent OsO(4) buffered at pH 7.3-7.5 with acetate-veronal buffer is recommended as an appropriate fixative for electron microscopy.

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Automated assessment of regional perfusion defects using FD and DCE MR imaging is comparable to visual scoring but allows for percentage-based analysis. These polymorphisms may represent genetic markers for the risk of HCC in the context of chronic HBV infection. A three-channel rigid endoscope system has been developed that allows simultaneous recording of stereoscopic and multispectral images. Expert commentary: Selection of a treatment approach in malignant pleural effusions should take into account patient preferences and performance status, tumor type, predicted prognosis, presence of a non-expandable lung, and local experience or availability. The use of uncemented stems remains controversial and issues regarding inferior fixation in osteoporotic bone, implant-related pain and decreased mobility have discouraged their use.

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Chemoreceptor Cells as Concentration Slope Detectors: Preliminary Evidence from the Lobster Nose. A total of 200 patients of both sexes without age limitation were evaluated, being directed to a Breath Test Laboratory for performing the H 2 test (100 patients) and of exhaled H 2 and CH 4 (100 patients) due to gastrointestinal complaints, most of them patients with gastrointestinal functional disorders.

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Our results indicate that the renoprotective effect of spironolactone when added to RAAS blockade is not mediated through anti-inflammatory pathways since markers of inflammation and endothelial dysfunction are not affected during treatment. Pyogenic granuloma, or granuloma pyogenicum, is a common, tumor-like growth of the oral cavity or skin that is considered to be an exaggerated, localized connective tissue reaction to a minor injury or irritation.

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Key facilitators included experiential learning, a group discussion platform, and goal setting with patients. This opens the way for several future applications of FePt NPs, including regenerative medicine and stem cell therapy in addition to enhanced MR diagnostic imaging. Furthermore, the IPDE method is a simple software program that does not require any expensive equipment or use advanced algorithms.

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In the docking model, the saccharide ligand is bound to one of these subsites, formed solely by heavy chain residues. Some physical properties of the tablets evaluated were weight uniformity, crushing strength, friability, tablet thickness and diameter liquefaction time and absolute drug content. She was started on Fluoxetine 20 mg/day and supportive interviews were organized. Properly folded active insect AFP was only detected when signal sequences were used to target proteins to the endoplasmic reticulum for secretion into the hemolymph. Two-unit cantilevered resin-bonded FPDs for single-tooth replacement appear to be reliable and predictable restorations, provided their preparations meet the right standards.

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In the present study, we investigated the mechanism by which G-Rb1 promotes cell cycle kinetics from the PC12 cells. Our findings are fairly congruent with what has been described in the literature on the use of this modality in prostate cancer.

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The researcher interviewed eight women ranging in age from 45 to 65. The prospects for clinical application of selective JAK2 inhibitors are discussed. Expert commentary: CPAP therapy is the gold standard treatment option and should continue to be offered to those who suffer from OSA.

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Arginine rich short linear motif of HIV-1 regulatory proteins inhibits dicer dependent RNA interference. Inguinal hernias involving the ureter, a retroperitoneal structure, is an uncommon phenomenon. The DA was found to have an impact on transfection kinetics in line with the observation that the rate of lysozyme-mediated nanoparticle degradation increases with the polymer DA. A clinical analysis of the recovery from sensory disturbance after sagittal splitting ramus osteotomy using a Semmes-Weinstein pressure aesthesiometer.

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A positive association between Cd and cancer mortality risk was identified for both genders. Conversely, the BOD of the final waste discharge was 4000 mg/ml during the dry season and 3,500 mg/ml during the wet season. The purpose of this study was to examine the effects of a cognitive training program on neurocognitive task performance and activities of daily living (ADL) in patients who had a stroke. Microbial pathogens exploit the clathrin endocytic machinery to enter host cells. Similarly, restriction of H5N1 replication in endothelial cells resulted in ameliorated disease symptoms and decreased viral spread in ferrets.

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Cross-sectional and longitudinal analyses were conducted on data collected from an NIH-sponsored RTT natural history study. In the past few years it has also become clear that the structure of membrane proteins, especially helical membrane proteins is determined, in part, by the membrane environment. We developed balloon dilation for bronchial stenosis via minitracheostomy. To test this hypothesis, young (6 to 8 weeks old) and aged (600 days old) mice were injected intravenously with a TSE agent.

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P0 (protein zero) mutation S34C underlies instability of internodal myelin in S63C mice. Changes of the circulating eosinophils thru insulin stress in normal and diabetics Acute effect of oatmeal on subjective measures of appetite and satiety compared to a ready-to-eat breakfast cereal: a randomized crossover trial.

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This sequestration is dependent on a hemimethylated oriC binding protein such as SeqA. Our results show that heavy metal pollution may pose high potential health risks to local residents, especially in the village closest to the mine (V1), mainly due to Pb, Cd and Hg. The approach was evaluated on two independent pathways using data from two microarray experiments. The impact of an additional external beam irradiation of the pelvis considering different prognostic criteria is still unclear. Nucleosome-depleted regions around transcription start and transcription termination sites were broad and more pronounced for active genes, with distinct patterns for promoters classified according to CpG content or histone methylation marks.

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This pathology is rare after blunt trauma and has not been previously described in literature. Diminazene aceturate (Berenil) has been widely used as a chemotherapeutic agent for trypanosomiasis in livestock since 1955. However, the chemotactic ability of the PPG treated HT-1080 was enhanced.

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However, the cause of these poisonings is still unknown, and comprehensive approaches are required to completely understand the problem. Requiring no sample pretreatment, the new method is simple, fast, more accurate than existing methods, and nondestructive of the fiber material.

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Isolation of interstitial fluid and demonstration of local proinflammatory cytokine production and increased absorptive gradient in chronic peritoneal dialysis. For migraine frequency data, standardized mean differences (SMDs) were calculated for individual studies and pooled across studies. Here, we identified gains of ubiquitylation sites in highly conserved regions of human proteins that occurred during human evolution. The aim of this study was to explore circadian clock regulation of cell proliferation and cell cycle gene expression in the zebrafish intestine. Here, we use conditional deletion and overexpression of mouse Inscuteable (mInsc) to analyze the relevance of spindle reorientation in cortical progenitors.

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Situations in which pro-oxidant mechanisms within the body are more active than the antioxidant mechanisms (oxidative stress) predispose and contribute to the pathogenesis of several ailments in various organs of the body. The overall density range at the perceptibility curve peak covered the clinical density range for each tube voltage and film type.

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We reviewed charts of patients younger than 18 years who underwent parotidectomy performed by a pediatric otolaryngologist between 1999 and 2011 at a tertiary pediatric center. A case of osteoblastoma of the talus in a 33-years old healthy male who presented to the foot and ankle clinic in October 2015 complaining of pain of the right ankle for 12 months following football injury is discussed.

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The second and third therapies were less effective and presented with more frequent and more intense side effects, especially hematologic toxicities and xerostomia. Moreover, the rs8042149 genotype x trauma exposure interaction was only associated with severity of the negative affect, anhedonia and dysphoric arousal symptoms in males. A dose-dependent impairment of leukocyte oxidative metabolism at a low pH could be demonstrated. Perioperative risk factors for adverse airway events in patients undergoing cleft palate repair. A phase 1 trial of imatinib, bevacizumab, and metronomic cyclophosphamide in advanced colorectal cancer.

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Remarkably, as we increased the number of end-groups, the micellar stability increased significantly and the range of enzymatic sensitivity spanned from highly responsive micelles to practically nondegradable ones. albescens) is also ethnopharmacologically applied to treat various symptoms such as inflammatory diseases. An understanding of the pathophysiology of celiac disease, in which the trigger (wheat, rye, and barley) is known, will undoubtedly reveal basic mechanisms that underlie other autoimmune diseases (eg, type 1 diabetes) that share many common pathogenic perturbations. Terminology Development for Whole Genome Study Approaches by Omics Technology and Hierarchy.

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Fifty-five studies describing JLS or/and aLoS were included for analysis. During prostate development, basal and luminal cell lineages are generated through symmetric and asymmetric divisions of bipotent basal cells. The participants indicated that current training and resources were inadequate to deal with the issue and further denominational support and seminary education was necessary. In addition, an overview is given about some previous published cases with BCOA who developed pancreatitis in the course of the disease.

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Mitochondrial genome sequence analysis is critical to the diagnostic evaluation of mitochondrial disease. The C7 to wall measurement is highly reliable in people with PD. Interleukin-6 inhibits the growth of prostate cancer xenografts in mice by the process of neuroendocrine differentiation.

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In other words, people with hypertension who engaged in vigorous PA reported less depressive symptoms. Instead, we found that heavy women received less post-secondary schooling than their thinner peers, which in turn adversely affected their occupational standing at each point in their careers.

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Lenke 1C and 5C spinal deformities fused selectively: 5-year outcomes of the uninstrumented compensatory curves. Reducing senescent cell burden by genetic approaches or by administering senolytics delays or alleviates multiple age- and disease-related adverse phenotypes in preclinical models. In particular, the reaction forces on the teeth and joints arose from contact, rather than nodal forces or constraints. Our results clearly demonstrated the appropriateness of the senescent vegetable cells for transferring into the production stage, due to the increased capacity to accumulate astaxanthin. The revised ABI-CA was pilot-tested with four children with ABI, aged 7-15 years, for a feasibility check.

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Safety based on measures of bleeding using the Thrombolysis in Myocardial Infarction (TIMI) classification system. Under these conditions, 70-80 survival (corresponding to size enlargement and weight gain) was observed with cryopreserved embryos and 20-25 percent of the plants regenerated (showing normal shoot and root growth) from cryopreserved embryos were established in pots. Bisphenol A can affect testosterone synthesis of mouse cultured in vitro through suppression of 3betaHSD ,P450scc, P450c17 and Vimentin. Using MRL/lpr mice, which are known to experience accelerated tissue damage after mesenteric IR injury, we sought to evaluate whether complement inhibition mitigates organ damage. This assay is in a homogenous assay format and has been miniaturized in a 1,536-well plate format for high throughput screening.

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The 10-year course of adult aggression toward others in patients with borderline personality disorder and axis II comparison subjects. Participants included 28 female undergraduate nursing students who had completed the nursing ethics course. The combination of metronomic cyclophosphamide, imatinib, and bevacizumab is safe and tolerable without significant drug interactions. Granulosa cells and fluid aspirated from the first follicle were used to determine IR isoform mRNA expression and insulin concentration, respectively.

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Favorable effects of walking levels on glycemic control have been hypothesized to be mediated through reductions in abdominal adiposity, but this has not been well studied. Optical Coherence Tomography: New Applications in Gastroenterology. Localized skin necrosis of steroid-induced striae distensae: an unusual complication of bevacizumab and irinotecan therapy. Finally, 17 NRT and 358 CR cases were followed up during surveillance.

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Although specific human immunodeficiency virus type 1 (HIV-1) drug resistance mutations are well studied, little is known about cumulative amino acid changes, or how regimen and participant characteristics influence these changes. These results demonstrate for the first time the presence of a second p53 interaction domain in BRCA1 proteins and suggests that BRCA1a and BRCA1b proteins, like BRCA1, function as p53 co-activators. The future of surgery requires the implementation of a number of assignments by the ACMT, the UEMS, its sections, boards and divisions.

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The mRNA expression levels of the indicated genes, including CCND1, CCNA1, EGFR, AR, CX3CL1, CXCL6, and CXCL1, were significantly increased in urinary bladder from CG and bladder cancer (BC) patients compared with healthy controls, while TP53 was decreased. There are two main types of prophylaxis: chemical and mechanical. Furthermore, anti-CD8 mAb administration did not induce donor-specific tolerance or cause nonspecific immune suppression, as indicated by the skin-grafting experiments.

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When general anesthesia is maintained with sevoflurane and remifentanil in patients undergoing laparoscopic gynecologic surgery, continuous infusion of low dose ketamine decreased early postoperative pain and the quantity of opioids used. Re-processing of biological products: regulatory considerations from the CBER perspective. In the current study, the authors found that poor compliance with specific therapeutic guidelines may contribute to this poorer outcome.

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These findings provide the first evidence that a frontal-thalamic structural perturbation mediates somatic psychotic phenomena in schizophrenia. An abnormal DRE correlated well with prostate cancer and independently predicted high-grade disease in these men. Congenital anomalies in newborns to women employed in jobs with frequent exposure to organic solvents--a register-based prospective study. Design of a dynamic model of genes with multiple autonomous regulatory modules by evolutionary computations. The prevalence of unmet need among respondents with various socio-economic characteristics was estimated to determine an inequity in the unmet need and the reasons behind it.

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Contemporary Anticoagulation Reversal Focus on Direct Thrombin Inhibitors and Factor Xa Inhibitors. So far, no such data have been available in renal transplant recipients.

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The mAbs partially inhibited the plating of pseudotypes of vesicular stomatitis virus (VSV) bearing envelope antigens dikloron gel nail of HTLV-I. Brief Report: Examining Executive and Social Functioning in Elementary-Aged Children with Autism. For years, scientists working with it have lacked a reliable genome sequence for comparison with other Actinobacillus species.

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We report a 8-year-old-boy spirolang 50 mg who presented like aHUS but the kidney biopsy showed MPGN type 1. Waist circumference measurement site does not affect relationships with visceral adiposity and cardiometabolic risk factors in children. It therefore seemed reasonable to compare this second generation of double-row constructs to the modified single-row double mattress reconstruction.

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An understanding of how ecological traits influence past species 500mg naproxen vs 800 mg ibuprofen and alcohol response to environmental change can aid our future predictions of species persistence. The density of CB1 receptors as well as the stimulation of GTP-binding proteins by WIN 55 212-2 were significantly increased in the substantia nigra of mice deficient in DOR. Major compounds were 2-phenylethanol, furfuryl alcohol, (Z)-3-hexen-1-ol, coniferyl alcohol, isoamyl alcohol and linolenic acid. Histological diagnosis was made from the surgical specimen in two patients and from an autopsy specimen in one patient. Here, we report the use of a fast conformational sampling strategy to improve the prediction of protein-peptide binding affinity.

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Optical density measurements and transmission electron microscopy verified that primycin kills bacterial cells without lysis. This series represents the largest collection of MRI examinations for SN in the literature to date and shows no association between OPG and SN. Beacon mRNA expression was demonstrated in isolated islets using RT-PCR and beacon-like immunoreactivity using immunocytochemistry (ICC) on a sections of post finasteride syndrome radio Bouin-fixed pancreas. Correction: Enhanced GAB2 Expression Is Associated with Improved Survival in High-grade Serous Ovarian Cancer and Sensitivity to PI3K Inhibition. We compared the ultrastructure and composition of this nuclear matrix preparation with the traditional high-salt nuclear matrix and with the third nuclear matrix preparation that we have developed from which chromatin is removed after extensive crosslinking.

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Patients who had undergone CTC in the period 1 January 2007 to 1 January 2011 were merged with all cases of CRC recorded in the Cancer Registry between 1 January 2007 and 1 July 2011 to identify all patients who had undergone CTC less than 2 years before CRC had been diagnosed. In the primary visual cortex of primates and carnivores, functional architecture can be characterized by maps of various stimulus features such as orientation preference (OP), ocular dominance (OD), and spatial frequency. Occluding surfaces frequently obstruct the object of interest yet are easily dealt with by the visual system. The provision of mechanical ventilation for the support of infants and children with respiratory failure or insufficiency is one of the most common techniques that are performed amantadine influenza treatment cdc in the Pediatric Intensive Care Unit (PICU).

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Striped field mice (Apodemus agrarius) are the main hosts for both vectors. Structured reporting using a shared indexed multilingual radiology lexicon. Can mandibular advancement prosthesis be used in the treatment of sleep apnea syndrome? Intracellular bacteria belonging to the genus Wolbachia have been described in filarial nematodes and spironolactone and alcohol interaction with lisinopril these microorganisms appear to have evolved an obligatory mutualistic association with their filarial hosts. There was substantial inter-observer agreement in the final assessment of solid breast masses by conventional US and ABVU.

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Though statistically no ovinum bodybuilding diet significant difference was observed between the two groups, sealant with ACP showed better retention than the illuminating sealant. The effect of stress on glycemic control in people with diabetes may be related to a direct effect of stress hormones on blood glucose levels and an indirect effect of stress on patient behaviors related to diabetes treatment and monitoring and meal and exercise plans.

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As the recent improvements in computing power mostly come from the increasing number of nodes in a system and the integration of heterogeneous accelerators, how to scale the computing problems onto more nodes and various kinds of accelerators has become a challenge for the model development. Neisseria gonorrhoeae was cultured from three aspirates and tamsulosin hcl oral 0.4 mg five urethral specimens. EGFR autocrine signaling in a compliant interstitial space: mechanotransduction from the outside in. The average 99Tcm-NC uptake of the whole wrist region was also measured and average E-rates were calculated.

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In plants evolutionary adaptations introduced specific structural changes within the valsartan side effects men AGC kinases that most likely allow modulation of kinase activity by external stimuli (e.g., light). Mental disorders in somatic diseases: psychopathology and treatment. The impacts of wind farms on local weather can be minimized by changing rotor design or by siting wind farms in regions with high natural turbulence.