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Aciclostad (Acyclovir)
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Acyclovir

Aciclostad is an antiviral medication. It is primarily used for the treatment of herpes simplex virus infections, chickenpox, and shingles. Other uses include prevention of cytomegalovirus infections following transplant and severe complications of Epstein-Barr virus infection. It can be taken by mouth, applied as a cream, or injected.Common side effects include nausea and diarrhea. Potentially serious side effects include kidney problems and low platelets. Greater care is recommended in those with poor liver or kidney function. It is generally considered safe for use in pregnancy with no harm having been observed. It appears to be safe during breastfeeding. Aciclostad is a nucleoside analogue that mimics guanosine. It works by decreasing the production of the virus's DNA.Aciclostad was patented in 1974, and approved for medical use in 1981. It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system. It is available as a generic medication and is marketed under many brand names worldwide. The wholesale cost as of 2014 to 2016 was between US$0.03 and US$0.12 for a typical dose by mouth. The cost of a typical course of treatment in the United States is less than US$25. In 2016 it was the 195th most prescribed medication in the United States with more than 3 million prescriptions.

Other names for this medication:
Acyclovir, Abduce, Acic, Aciclobeta, Aciclomed, Aciclostad, Aciclovirum, Acifar, Acihexal, Aciklovir, Acitop, Acivir, Acivirex, Acivision, Acix, Actios, Activir, Acycloguanosine, Acyl, Acyrax, Acyvir, Aklovir, Antivir, Asiviral, Avir, Aviral, Avix, Avorax, Blistex, Cicloferon, Cicloviral, Clinovir, Clirbest, Clopes, Clovate, Clovir, Cusiviral, Cyclomed, Cyclovax, Cyclovex, Cyclovir, Danovir, Declovir, Epsin, Eurovir, Hascovir, Hernovir, Herperax, Herpesil, Herpesin, Herpex, Herpin, Herplex, Heviran, Immunovir, Lisovyr, Lovir, Lovire, Lovrak, Medovir, Menova, Ocuvir, Poviral, Ranvir, Remex, Rexan, Scanovir, Sitavig, Sophivir, Soviclor, Supraviran, Telviran, Uniplex, Vilerm, Viraban, Viralex, Viratac, Viratop, Virest, Virestat, Virex, Virless, Viroclear, Virolex, Viromed, Virosil, Virostatic, Virovir, Virucid, Viruderm, Virustat, Virux, Vivorax, Xiclovir, Xorox, Zevin, Ziverone, Zoral, Zorax, Zoraxin, Zovirax,

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This medication is used to treat "cold sores/fever blisters" (herpes labialis). It can speed up healing of the sores and decrease symptoms (such as tingling, pain, burning, itching). Aciclostad belongs to a class of medications known as antivirals. It works by stopping the growth of the virus. This medication does not cure herpes, and it does not prevent passing the infection to someone else. It does not prevent a future occurrence. OTHER This section contains uses of this drug that are not listed in the approved US professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional. This medication may also be used to treat genital herpes. Other medications taken by mouth may be more effective for genital herpes. Discuss your treatment options with your doctor. This medication does not cure herpes or prevent infection of sexual partners.

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Asymptomatic subjects underwent endoscopy followed by 24-h HMII using a specialized impedance catheter configured to detect LPR before and after a 2-week course of proton pump inhibitors (PPI). The LVL approach for peripheral blood progenitor cells (PBPC) collection in very small children may expose them to the risk of anemia and thrombocytopenia and an excess of special central line installation.

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In addition, the control of receptivity is likely to be the subject of sexual conflict over remating frequency. Worsening enterocolitis in neonates: diagnosis by CT examination of urine after enteral administration of iohexol. The SA-VMAT technique achieves highly conformal dose distribution to the target. The only possible area of concern is in an oncology ward, where patients may be regularly referred for PET investigations and other high activity radionuclide studies and are partially helpless.

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To determine whether subscapularis, infraspinatus, and teres minor (anteroposterior force couple) muscle activation differ between 4 shoulder exercises and describe coactivation ratios and individual muscle-recruitment characteristics of rotator-cuff muscles throughout each shoulder exercise. During follow-up our patient underwent five radioiodine therapy procedures (5.3 to 5.7 GBq each) over a two-year period.

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Two-stage revision of infected total knee arthroplasty using antibiotic-impregnated articulating cement spacer Retrospective cohort study linking inpatient, outpatient, and laboratory databases for cohort assembly and logistic regression analysis. Surprisingly the same protein accumulated in the mitochondria of a stable HeLa cell line, suggesting a differential localisation of CeHCF in mammalian cells. By extending this research, scientists may be closing in on ways to lengthen the human life-span.

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Reliability was assessed using the intraclass correlation coefficient. We found that the subjects who had the T allele as one of the alleles (A/T or T/T genotypes) at the -3081(A/T) polymorphism showed a better response to MPH treatment than those with the A/A genotype as measured by the CGI-I. We recently demonstrated that the suprachiasmatic nucleus (SCN) responds to GABAergic stimulation differently in diurnal and nocturnal animals.

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Sequence analysis, primer extension, and RT-PCR experiments indicated that ffdB is part of an operon harboring three additional open reading frames (ffdA, ffdC, ffdD). Accuracy of prediction equations to estimate submaximal VO2 during cycle ergometry: the HERITAGE Family Study. In parallel we have studied the levels of DNA damage in the exposed tissues. Development of an integrative vector for the expression of antisense RNA in Clostridium difficile. Electrophoretic analysis showed protein bands corresponding to alpha-galactosidase and invertase activities.

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Besides the conventional therapeutic measures, Penta-association therapy was also applied in the two groups, which consisted of blood purification (adsorption of triglyceride and hemofiltration), antihyperlipidemic agents (fluvastatin or lipanthyl), low molecular weight heparin (fragmin), insulin, topical application of Pixiao (a traditional Chinese medicine) over the whole abdomen. Results indicate that HER-2 expression is only downregulated following p53 silencing and none of cyclin E isoforms can alter its expression. Looking back, looking ahead: primary healthcare renewal in Canada.

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Should anatomical circumstances such as excessive adipositae, very large carcinomae, narrow pelvis and enlargement of the uterus or prostata prevent the safe dissection of the mesorectum a sphincter-retaining operation is also not indicated. It reviews and summarizes our current knowledge on this area and discusses future strategies to identify new biomarkers that could be used to personalize RCC management. All tested cell population showed a similar fibroblast-like morphology and superimposable immunophenotype. Uncontrolled prospective observational study with 557 consecutive hospital patients. All of our patients showed improvement, with an overall patient satisfaction score of 2.65.

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Furthermore, innovative biotechnological approaches allow to take a step forward towards the development of new improved cultivars harboring precise genome modifications. Differential expression of HMGA1 and HMGA2 in dermatofibroma and dermatofibrosarcoma protuberans: potential diagnostic applications, and comparison with histologic findings, CD34, and factor XIIIa immunoreactivity.

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Chronic Mycobacterium leprae infection usually leads to overt leprosy with neurological and cutaneous involvement. Examination of the cognitive abnormalities of EOS offers the opportunity to explore how disease-related mechanisms may affect facets of cognitive development. A long list of clinical and patient-reported outcomes was identified and categorized into outcome domains.

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The connectivity of the deformed template model is automatically adjusted to facilitate the geometric fitting and to ascertain high quality of the mesh elements. A cross-sectional survey was conducted on 240 households for both the endemic (Vaishali district) and non-endemic (Lohardaga district) site.

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Selective antagonism of micro opioid receptors, but not delta opioid receptors, allowed lower concentrations (1-100 microM) of morphine to inhibit LHRH. Symptoms vary and range from asymptomatic to severe heart failure and sudden death. The use of an immunomodulating leukocyte selective cytopheretic inhibitory device is also reviewed as an example of this cell processing approach.

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If there is a contribution to the dielectric permittivity tensor of odd order in the magnetization, the modes propagate differently in the forward and the backward directions. Physical demands on young elite European female basketball players with special reference to speed, agility, explosive strength, and take-off power. Optical coherence tomography (OCT) is emerging as a new gold standard for endovascular imaging of stents, atherosclerosis progression, vulnerable plaque, and neointimal proliferation. ALK7 is also expressed in adult rat islets and pancreatic beta-cell-derived MIN6 cells.

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The effects of the etchants on the stability of Au catalysts were examined in detail. Serological methods for the diagnosis of Salmonella infections vary widely and the most commonly used test is limited by high running costs as well as low sensitivity and specificity. Children learned in small groups, receiving two sessions of roadside training followed by four on a table-top model. Analysis of RadLex coverage and term co-occurrence in radiology reporting templates.

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In this in vitro setting, the Aperio device seems to be an efficacious and safe device when compared to other similar clinically used mechanical thrombectomy devices. The present study examined expressive incoherence in 37 children with ASD and 41 typically developing (TD) children aged 3-13 years old during a frustration task. Comparative genomics of the pathogenic ciliate Ichthyophthirius multifiliis, its free-living relatives and a host species provide insights into adoption of a parasitic lifestyle and prospects for disease control. In this work, we calculate, via embedded n-electron valence second-order perturbation theory within the density functional embedding theory, the excited-state potential energy surfaces for dissociation of N2 on an Fe-doped Au(111) surface. Altered Effective Connectivity Network in Childhood Absence Epilepsy: A Multi-frequency MEG Study.

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For children younger than 8 years, pressurized metered-dose inhalers with spacers are the most appropriate devices, since they provide a practical approach associated with greater lung deposition. Flow-cytometry and immunohistochemistry were used to quantify tumor-infiltrating lymphocytes (TIL) elicited by treatment and assess their activation status and cytolytic potential. At Argonne National Laboratory, 22 external beam studies were conducted on nearly 700 beagle dogs and 50,000 mice between 1969 and 1992. The REDUCE metagram: a comprehensive prediction tool for determining the utility of dutasteride chemoprevention in men at risk for prostate cancer. Due to their amphiphilic nature they assemble in aggregates in water and their photophysical properties, as well as the morphological characterization of the assemblies are presented.

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Galectin-3 in ambulatory patients with heart failure: results from the HF-ACTION study. Gene duplication in the carotenoid biosynthetic pathway preceded evolution of the grasses. Initiation of a sepsis protocol, which emphasizes early goal-directed therapy, can improve time to administration of first dose of antibiotics.

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Effects of umbilical cord blood monocytes transplantation on EPO protein and oligodendrocyte progenitors in neonatal rats with hypoxic-ischemic brain damage Our results indicate that ICT accessibility has a strong association with effective delivery of public health. Nutritional status, dietary intake and oral quality of life in elderly complete denture wearers. To determine whether preoperative helical CT angiography (CTA) with three-dimensional (3D) reconstructed images improves outcome in patients with ureteropelvic junction obstruction (UPJO) by identifying crossing vessels that may lead to surgical failure.

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During partnered sexual activities, both ejaculatory control and ELT could be accurately predicted by observing ejaculatory control at prior events. We then evaluate the power of various weighting schemes as a function of variant characteristics, such as MAF, the proportion associated with the phenotype, and the direction of effect.

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Role of the activation of the nuclear enzyme poly(ADP-ribose) polymerase in the pathogenesis of periodontitis. Using data from the Household, Income and Labour Dynamics in Australia (HILDA) Survey, this paper investigates the influence of economic, personality and social factor demographics on the incidence of obesity in Australian youths. Special emphasis is placed on critically ill obstetric patients with concomitant cardiac disease. 3C expression also induced activator protein 1 and NF-kappaB transcriptional activation. Many experts have suggested that blunt splenic trauma in patients older than 55 years should not be managed by observation because of supposed increased fragility of the spleen and decreased physiologic reserve in elderly patients.

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Time-dependent effects of intrahippocampal galanin on spatial learning. Following a systematic search across several publication databases, meta-analyses were conducted for 27 empirical studies that compared euthymic adult MDD patients (895 participants) and healthy controls (997 participants) across a range of cognitive domains. Nursing observation chart: between the objectives targeted by this model and actual practice, where should we place the reflective process of the nurse? A Bayesian spatial conditional autoregressive model was fitted at the LGA level to quantify the relationship between DF and socioecological factors. Unlike previous attempts to connect the lattice Boltzmann method with the kinetic theory, the result is free of any relaxation-type approximation.

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Quantitative SPECT/CT: SPECT joins PET as a quantitative imaging modality. Unlike nateglinide, rosiglitazone (5 micromol/L), troglitazone (1 to 10 micromol/L), or darglitazone (10 micromol/L), 3 peroxisome proliferator-activated receptor gamma (PPARgamma) agonists, were without any acute stimulatory effect on insulin release in the simultaneous presence of 6 to 10 mmol/L glucose. A sample of 130 consecutive adult inpatients with unipolar depression and Montgomery-Asberg Depression Rating Scale score over 18 will be recruited. The sites of aberrant methylation are potential markers of neoplastic transformation. The variations detected were evaluated in available family members as well as 110 normal controls.

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This work presents our text mining algorithm and demonstrates its use to uncover information that could form the basis of new hypotheses. PPI interfaces are large, up to thousands of square angstroms, and there is still debate as to what part of the interface one should target. Several peptides that included in their sequences amino acids from the CDRs of the antibody and framework residues flanking the CDRs were found to bind soluble CD4.

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