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This medication is used to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This product contains 2 medications, metoprolol and hydrochlorothiazide. Metoprolol belongs to a class of drugs known as beta blockers. It works by keeping certain natural chemicals such as epinephrine from acting on the heart and blood vessels. This effect lowers the heart rate, blood pressure, and strain on the heart. Hydrochlorothiazide is a "water pill" (diuretic) and causes your body to get rid of extra salt and water. This effect may increase the amount of urine you make when you first start the medication. It also helps relax the blood vessels so that blood can flow more easily. OTHER This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional. This drug may also be used to treat heart failure.

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The SiiE C-terminal moiety including immunoglobulin (Ig) domain 53 is essential and sufficient for mediating type I-dependent secretion of Gluc. Ground states of the Ising model on an anisotropic triangular lattice: stripes and zigzags.

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Influence of stormflow and baseflow phosphorus pressures on stream ecology in agricultural catchments. In all dogs, small, focal, round or linear lucent defects were visible within the cortical bone at the junction of the greater tubercle and intertubercular groove. Attraction to and transmigration of immune cells into the interstitium is associated with increased vascular permeability and loss of endothelial and tubular epithelial cell integrity. Residents who are successful in executing administrative duties, provide safe patient care, or obtain high scores on examinations may have a DISC profile that is high in Dominance and Conscientious/Compliance but lower in Steadiness/Submission and Influence.

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We could demonstrate that secretion-deficient as well as secretion-competent YopE-DHFR fusions complexed to SycE can be efficiently purified from Yersinia cytosol by affinity chromatography using methotrexate-agarose. In conclusion, pelvic allografts represent a valid option for reconstruction after resection of pelvic tumours but due to the associated morbidity, patients should be carefully selected. Expression of the 3-phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in PTEN-null U87MG cells revealed differential sensitivity of these lipid pools to the enzyme. These methods do a better job of approximating what the imagery should be but are not exact and tend to be view-dependent. The use of systemic glucocorticosteroids and an influence of the systemic inflammatory response have been suggested as contributing to low testosterone levels.

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Slow dynamics in gelation phenomena: from chemical gels to colloidal glasses. Mice of exposed group were intoxicated by inhalation of phosgene 11.9 mg/L for 5 minutes. Secondary outcomes were other adiposity measures, physical activity, diet, sedentary behaviour and screen time. There were concomitant decreases in the proportion of participants who said that they would refer patients requiring these surgical procedures.

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The data used in the analysis were collected in focus group interviews and household-level surveys of the elderly (defined as ages 60 and over) in Singapore and Taiwan. This study suggests that site-specific excision of proviral DNA of HIV-1 could be catalyzed by the least modified Cre recognizing the loxLTR-1 sites. Overall predictors of outcome for patients undergoing endovascular treatment of SRA include age, aneurysm size, Hunt and Hess grade, location and post-treatment vasospasm.

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Three prospective nonrandomized studies compared NB-UVB with excimer laser phototherapy. Systemically administered ANG1005 and Cy5.5Angiopep-2 localised to orthotopic glioma tumours in mice. Conversely, molecular activation of DVC Drp1 in healthy rodents was sufficient to induce DVC mitochondrial fission, ER stress, and insulin resistance. Prevalence of hepatitis A and chronic hepatopathies: a challenge to be developed Their use must be managed with great attention in occupational settings to avoid serious detrimental effects to the health of employees.

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Moreover, with the exception of the mental health score, HRQoL was not significantly affected by the type of chemotherapy. In addition, the difference-frequency scattered pressure in all scattering configurations decays as r(-1)lnr and 1/r, where r is the radial distance from the scatterer to the observation point. We identified all women 30-39 years of age who underwent imaging evaluation (ultrasound and mammography) at our institution between January 1, 2002, and August 31, 2006, for focal breast signs or symptoms. Down-regulation of XIAP may be responsible for enhancement or restoration of TRAIL sensitivity after CHX treatment in B-lymphocytic leukaemia cells.

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Differences in end-of-life (EOL) care preferences (eg, location of death, use of life-sustaining treatments, openness to hastening death, etc) based on hypothetical death scenarios and associated physical and/or cognitive losses have yet to be investigated within the palliative care literature. The information was analyzed by the ROC (Receiver Operating Characteristic Curve) method. Based on nearly two hundred cases identified in police records and other sources as partner killings between 1925 and 1945, this analysis compares lethal violence in legal marriages and in common-law unions.

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Genetic inactivation of STAT6 in a PKD mouse model leads to significant inhibition of proliferation and cyst growth and preservation of renal function. Intraoperative EC-IC bypass blood flow assessment with indocyanine green angiography in moyamoya and non-moyamoya ischemic stroke. The aim of this study was to clarify the specific miRNAs in serum that could predict the early response of HCC to sorafenib treatment.

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The influence of birth weight on cortical thickness, surface area, and striatal and total brain volumes was investigated, controlling for variance in age, sex, household income, and genetic ancestry factors. Route of jejunal mucosa absorption of trypsin demonstrated by immunofluorescence. We tested the hypothesis that HPV-associated HNSCCs display a pattern of genetic alterations different from those of HNSCCs without HPV DNA. Krathom is addictive with its own characteristic symptoms and signs.

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The incidence of MI and cardiac death were not different between Europe and Asia. Our results suggest that the male population is at oxidative risk when compared with females, especially between the age of 2 and 7 years. Structure coefficients and commonality analysis indicated that anhedonia served as a suppressor variable for the other symptom clusters. Crystal structure and characterization of particulate methane monooxygenase from Methylocystis species strain M.

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For miscellaneous conditions, the available evidence is limited and is neither compelling nor conclusive. In this study, SW480 cells were transfected with hsp70 cDNA in either the sense or antisense orientation and stable clones were selected and tested for their sensitivity to curcumin. Our results show the utility of the HyPer-DAO genetically encoded system for redox signaling studies and suggest that H2O2 produced by DAO in the cytoplasm acts locally in close proximity to the enzyme. At the same time, the molecular mobility of the multilayers allows for self-assembly of the particles in regular two-dimensional arrangements.

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Oligopeptides derived from autophosphorylation sites of EGF receptor suppress EGF-stimulated responses in human lung carcinoma A549 cells. Participants faced continuous cross traffic traveling at 25 mph or 35 mph and waited for gaps they judged were adequate for crossing. These effects act as potential confounding variables that complicate the interpretation of results. Talpha1 is a biologically active peptide made up of 28 amino acids that can enhance T-cells, dendritic cell and antibody responses, modulate cytokines and chemokines production.

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Neuronal pathways involved in stress responses to extreme somatosensory stimuli were investigated by immunostaining, viral tract tracing, and experimental brain surgery in rats. d-Cycloserine is a second-line drug approved for use in the treatment of patients infected with Mycobacterium tuberculosis, the etiologic agent of tuberculosis. The suitability of this procedure was demonstrated by its application to an in-house validation for the determination of plasticizers in plastic food packaging by GC. IgE, but not IgG4, antibodies to Ara h 2 distinguish peanut allergy from asymptomatic peanut sensitization.

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Intra-operatively the ulnar nerve was found to be embedded between fragments of the fractured ulna, which showed lack of callus formation on the preoperative radiograph. The best choice of treatment is curative resection of the primary lesion.

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Her-2/ neu altered peptide ligand-induced CTL responses: implications for peptides with increased HLA affinity and T-cell-receptor interaction. ICS therapeutic equivalence can be assessed by reduction in eosinophil counts tested in steroid naive subjects. and their application in diagnosis of diseases at proteomics level have also been discussed. Intra-arterial administration of procaine in post-traumatic conditions of the lower extremities and in dry gangrene Thus, its clinic diagnostic biomarkers are important when it comes to reducing mortality and morbidity rates.

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We describe a patient with severe facial apraxia caused by contusion in the right frontal operculum, premotor area and primary motor cortex ipsilateral to the dominant hand. The results were then compared with the histopathological findings. Here we follow the phosphorylation of this site in intact T-cells. The decolorization and detoxification potential of WRF can be harnessed thanks to emerging knowledge of the physiology of these organisms as well as of the biocatalysis and stability characteristics of their enzymes.

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In this case report, we describe two patients with an initial presentation consistent with anti-NMDAR encephalitis who have subsequently developed relapsing-remitting multiple sclerosis (MS) and discuss the literature pertaining to potential overlap between NMDAR encephalitis and inflammatory demyelinating disorders. In the presence of either ATP or ADP, phosphorylation increased the solvent exposure and decreased the polarity of the environment about position 23 of the regulatory light chain of heavy meromyosin. tuberculosis clinical isolates and demonstrated significant structural variations.

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This host response alters many serum protein levels in cancer patients, but these changes have low specificity as they can be triggered by diverse causes. Increased intestinal permeability with subsequent metabolic endotoxemia, i.e., elevated circulating levels of bacterial lipopolysaccharide, LPS, has been introduced as a novel initiator of obesity related metabolic disturbances in non-pregnant individuals. Bowhead whales are highly adapted to polar sea ice and were targeted by commercial whalers throughout Arctic and subarctic seas for at least four centuries, resulting in severe reductions in most areas. A significant IOP decrease was observed during the first weeks after DSCI and DS.

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Besides history, symptoms and physical examination electrodiagnostic and imaging are necessary for establishing the correct diagnosis. In order to facilitate the use of this new method within any practical context, a function in the language R has been developed.

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Complex permittivity of representative biological solutions in the 2-67 GHz range. pH-triggered aggregate shape of different generations lysine-dendronized maleimide copolymers with maltose shell.

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Absolute triply differential cross sections for double photoionization of helium at 10, 20, and 52.9 eV above threshold. One of the most challenging hurdles for interpreting in vitro toxicity findings is the need for reverse dosimetry tools that estimate the exposures that will give concentrations in vivo similar to the active concentrations in vitro.

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A 24-item survey regarding current practices of endoscopy, sedation and monitoring in gastrointestinal endoscopy was sent to 4 405 members of the German Society of Digestive and Metabolic Diseases (DGVS). Comparison of 2.5 vs 7.5 mg of inhaled albuterol in the treatment of acute asthma. The authors examined the correlation among histologic subtypes, outcomes, and patterns of recurrence among patients with extremity liposarcomas.

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Postoperative convalescence (return to work or normal activities) was between 3 and 5 days after TAPP in patients who were counseled about a 1-day expected convalescence. Perihematomal endothelin-1 level is associated with an increase in blood-brain barrier permeability in a rabbit model of intracerebral hematoma. The Cochrane Central Register of Controlled Trials, PubMed/MEDLINE and EMBASE were searched for all randomized controlled trials and prospective observational studies comparing the efficacy of n-3 PUFAs versus control in adult patients with psoriasis. Human tryptophanyl-tRNA synthetase (TrpRS) is active in translation and angiogenesis.

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Herstatin inhibits heregulin-mediated breast cancer cell growth and overcomes tamoxifen resistance in breast cancer cells that overexpress HER-2. Existing data further indicate that right ventricular function is more affected than left ventricular function.

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Increasing the sufficiency of labor pains through the sympathetic and parasympathetic nervous system Several studies have demonstrated that a specific 4q35.2-located haplotype (4qA161) is also closely associated with FSHD expression. Control electronics for proper bump strength settings were designed to incorporate the existing orbit-corrector function. Isolation of selected analytes was performed using the methods of liquid-liquid extraction and cold extraction.

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Phenylephrine increases pulmonary blood flow in children with tetralogy of Fallot. Renal nitric oxide production is decreased in diabetic rats and improved by AT1 receptor blockade. An extremely sensitive adsorptive wave of BSA at about -1.73 V (vs SCE) has been obtained in the solution containing 8 x 10(-)(7) mol/L CoCl(2), 0.2 mol/L guanidine hydrochloride, and 0.2 mol/L NaOH by using single-sweep polarography. The 80-mg betrixaban dose achieves higher plasma concentrations than the 40-mg dose and, in contrast to the 40-mg dose, is associated with improved efficacy across all cohorts relative to standard-dose enoxaparin without an excess risk of major bleeding in the management of medically ill subjects.

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Knockdown of NYGGF4 (PID1) rescues insulin resistance and mitochondrial dysfunction induced by FCCP in 3T3-L1 adipocytes. Clinical immunogenicity of the d-amino acid peptide therapeutic etelcalcetide: Method development challenges and anti-drug antibody clinical impact assessments.

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All patients that presented with anticholinergic plant poisoning between July 1990 and June 2000 were included. In this study the rate of institutionalization in old age for the first time is analyzed on a retrospective data set: the Altenheimsurvey and the Socio-Economic Panel-Survey. There was a significant correlation between EBCT CC score and coronary index, but receiver-operating characteristic (ROC) analysis demonstrated unsatisfactory performance of EBCT CC, and 6 patients had no coronary calcification despite having very abnormal coronary indexes. As the drugs currently used to treat these diseases have several disadvantages and side effects, there is an urgent need for new drugs with better selectivity and less toxicity.

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Levels of shared care were categorised into low, medium and high tertiles. These data may prove useful as a reference for future comparative studies of different corneal diseases in children. Resting metabolic rates at thermoneutral (RMRts) are unexpectedly variable.

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To further characterize these pathogens, molecular analyses based on citrate synthase and heat-shock operon genes were also performed. The challenges of health care reform for hospital social work in the United States.

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Using the Resident Assessment Instrument-Mental Health, an assessment that is used to collect demographic and clinical information within 72 hours of hospital admission, 199 geriatric mood disorder admissions were compared with 570 adult mood disorder admissions. Determination of the optimum number of cardiac cycles to differentiate intra-pulmonary shunt and patent foramen ovale by saline contrast two- and three-dimensional echocardiography. Extended anticoagulation prophylaxis is a hypothesis for patients after LSG, and may play a role in preventing PMVT. The protein-fatty acid interaction was specific, as saturated C18 fatty acids, or unsaturated C18:1trans conformers were unable to form complexes with apo alpha-lactalbumin, as were fatty acids with shorter or longer carbon chains. A novel short time-series expression miner algorithm identified protein clusters with coherent changes during injury and repair.

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In human primary cell lines from a squamous cell carcinoma (SCC) of the vulva, the effect of cisplatin (CDDP) and IFNgamma on the expression of CD95L and its 2 receptor isoforms, CD95 transmembrane (CD95tm) and CD95 soluble receptor, was studied at the mRNA and protein levels. The aim of this study was to determine whether pooled serum and meat juice could be used to identify finishing pig herds with a high prevalence of infection. A total of 40 children (aged 6 months to 11 years) with CF in stable condition and 18 healthy age-matched control subjects. In addition, anisomycin had no effect on a long-lasting version of latent inhibition of cued fear conditioning that was maintained over a 7-day interval.

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DNA-based HIV vaccines do not induce generalized activation in mucosal tissue T cells. Fifty-eight patients with LCP were recruited at initial presentation and followed for 1 y.

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The results indicate that the chaotic nature of rotor pivot point results in higher Kurtosis compared to the periphery thereby enabling its accurate identification. DNA methyltransferases flip their target base out of the DNA helix. Loss of PTEN is one of the most common mutations in prostate cancer, and loss of wild-type TP53 is associated with prostate cancer progression and castrate resistance.

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Monthly culture is usually recommended to monitor treatment of multidrug-resistant tuberculosis (MDR-TB). We acquired OCT images of periodontal pockets in a porcine model and determined the actual axial resolution for measuring the exact periodontal pocket depth using a calibration method. The lower glucose threshold used by ADA almost triples impaired fasting glucose prevalence compared to WHO/IDF criteria. The medial lower arm of Y ligament was attached to the upper and anterior surface of the superior articular process of the lower corpus vertebra. To determine the proportion of patients assessed by the clinical team to have decisional capacity on admission, how many of these patients participated or had a surrogate participate in a discussion about end-of-life care, and whether patient participation was associated with treatments received.

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To enhance the versatility of this plasmid-based approach for mycobacterial protein expression, the Escherichia coli/mycobacteria shuttle plasmid pGB9 was modified to accommodate mycobacterial genes expressed from their endogenous promoters. CT fluoroscopy-guided percutaneous vertebroplasty in patients with multiple myeloma: analysis of technical results from 44 sessions with 67 vertebrae treated. From E14.5 to birth, C61 was highly expressed in all neuronal differentiation fields, with the highest signal in the telencephalic cortical plate and mitral cells in the olfactory bulb.

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The sample studied had an average of 1 year of drug abstinence and was found to have poorer sexual functioning than the control group. Hepatobiliary cystadenocarcinoma with cystadenoma elements of the gall bladder in an old man. The objective of this study was to compare the effects of low-fidelity simulator (LFS) versus HFS technology on performance levels, objective and subjective measures of stress in neonatal trainees. Arterial stenting and balloon angioplasty in ostial atherosclerotic renovascular disease: a randomised trial. The use of plasma membrane vesicles that overexpress the bile salt export pump (BSEP) or multidrug resistance-associated protein 2, 3, or 4 (MRP2-4) with an in vitro vacuum filtration system offers a rapid and reliable means for screening drug candidates for their effects on transporter function in hepatocytes and thus their potential for causing drug-induced liver injury (DILI).

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Altered transport functions in the placenta might contribute to adverse outcome of pregnancies in women with diabetes. This could be used in exploring different aspects of structural and functional organization of origins including interactions between closely spaced origins. Spitz is a potent ligand, whereas Vein is an intrinsically weak activating ligand. Twelve months after transplant the patient is in NYHA functional class I with normal biventricular function.

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The B-cell transcription factors BSAP, Oct-2, and BOB.1 and the pan-B-cell markers CD20, CD22, and CD79a are useful in the differential diagnosis of classic Hodgkin lymphoma. The analyses of the WPC revealed that the factors closely associated with gel strength and water-holding capacity were solubility and composition of the protein and the ionic environment.

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Several days prior to the hussein visram name examination, participants completed a series of questionnaires assessing depression and anxiety. Personality development: an introduction toward process approaches to long-term stability and change in persons. The study results indicated that hUCMSCs can differentiate into urothelium-like cells in a defined micro-environment in vitro constituted by UC-CM and exogenous EGF. The medication has shown promise in early trials in patients with heart failure, but it is unclear if this agent will be beneficial in patients with stable coronary artery disease without heart failure. Podocyte expression of nonmuscle myosin heavy chain-IIA decreases in idiopathic nephrotic syndrome, especially in focal segmental glomerulosclerosis.

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Controversy over the use of creatine as a safe dietary supplement. Considering ulcratex 20 mg precious movie the striking differences between the signaling requirements of FcgammaR in macrophages and NK cells, our findings suggest that the organization of signal transduction downstream of the same FcR can be cell type-specific. Helicobacter pylori were detected in dental plaque samples through PCR assay. Predicting the pathogen of diabetic toe osteomyelitis by two consecutive ulcer cultures with bone contact.

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Identification valsartan 160 mg in spanish of distinct binding sites for monovalent and divalent cations. A novel time-resolved diagnostic is used to record the critical surface motion during picosecond-scale relativistic laser interaction with a solid target. Isolation and characterization of microsatellite markers for an important tropical tree, Aquilaria malaccensis (Thymelaeaceae).

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Regional distribution of organochlorinated pesticides in pine needles and its indication for socioeconomic development. PDUS seems to be a reliable tool in the assessment of SLE patients with HA. Finally, the coupling of a reactive vinyl halide could be achieved by the use of a very hindered ligand and more reactive, branched allylic dydrogesterone side effects pregnancy symptoms acetates. We investigated the presence of IR in patients with chronic pancreatitis (CP) and compared the same with the underlying etiology.

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Nucleation and growth in pressure-induced phase transitions from molecular dynamics simulations: mechanism of the reconstructive transformation of NaCl to the CsCl-type structure. The synthetic standard of (9R)-3,5-syn-3,5,9-trimethyldodecanal gave identical chromatographic and mass spectrometric data as the natural pheromone and also was active reactions to antibiotics clarithromycin 500mg in electroantennographic and behavioral assays.

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The data suggest that patients with RDP do not have a decrease in the number of dopamine re-uptake sites. Those proteins showed strong enrichment for common human RNA binding domains such as RRM, RBD, as well as K homology and CCCH type zinc finger motifs. Postmenopausal hormone therapy and colorectal cancer risk by molecularly defined subtypes among acyclovir shingles pregnancy risks older women.